Aeolian Advisors works with clients to identify appropriate investment opportunities among small and emerging growth biotechnology and medical device companies, offering to develop and identify suitable opportunities to allow inclusion into or the development of a diversified portfolio for: investment companies (including "business development companies" that have made an election pursuant to section 54 of the Investment Company Act of 1940); pooled investment vehicles (other than investment companies); and, businesses (other than small businesses) or institutional clients. Such investments may serve part of a broader investment portfolio.

Aeolian Advisors’ focus is on those privately held or thinly-traded bulletin board listed securities, typically have no revenues and no prospects for any near or mid-term revenues. As such they must be considered very high risk, speculative, illiquid investments that can be difficult to sell and value due to limited market participants, infrequent transactions, complex structures or highly uncertain future performance.